作者：陳積趙小倩胡姍姍馬彥巧劉燕譚丹楓陳澤慧田應彪**：《中國藥房》2023年第05期
中圖分類號 r283 文獻標誌碼 a 文章編號 1001-0408（2018）05-0615-06
doi 10.6039/
摘要目的：製備複方莪朮油脂質體（ztoc-lps）並對其質量進行評價。方法：
以複方莪朮油中莪朮油（以吉馬酮表徵）和維a酸的包封率及載藥量等為考察指標，篩選ztoc-lps的製備方法及處方中大豆卵磷脂（spc）的加入量、脂質中spc-膽固醇（ch）質量比、莪朮油-脂質質量比、維a酸-脂質質量比、水浴溫度；並對最優處方製備工藝所製脂質體進行質量評價和初步穩定性考察。結果：優選的製備方法為乙醇注入法；最優處方製備工藝為每1 ml脂質體中spc 4 mg、spc-ch質量比3 ∶ 1、莪朮油-脂質質量比1 ∶ 9、維a酸-脂質質量比1 ∶ 70、水浴溫度55 ℃。
所製3批脂質體中莪朮油和維a酸的平均包封率分別為（64.63±1.00）%和（90.
33±0.72）%，載藥量分別為（9.09±0.
14）%和（1.43±0.02）%，粒徑為（257.
41±7.58） nm，zeta電位為（-38.77±0.
81） mv，多分散係數為 0.10±0.04；離心加速試驗結果顯示脂質體具有良好的物理穩定性；脂質體樣品在（4±2） ℃條件下放置 1 個月時各項考察指標均未發生明顯變化。
結論：建立的製備方法簡單可行，所製脂質體質量符合要求，可為後續複方莪朮油新劑型的研究提供參考。
關鍵詞莪朮油；維a酸；脂質體；包封率；載藥量；製備工藝；質量評價abstract objective： to prepare zedoary turmeric oil compound liposomes （ztoc-lps） and evaluate its quality. methods：
the preparation method of liposome， the addition amount of soybean phosphatidylcholine （spc）， ratio of spc to cholesterol （ch） in lipid， drug-lipid ratio of zedoary turmeric oil （zto）， drug-lipid ratio of tretinoin in formulation， and water bath temperature were screened using encapsulation efficiency and drug-loading amount of zto （represented by germacrone） and tretinoin as investigation indexes. quality evaluation and primary stability investigation were conducted for liposomes prepared by optimal preparation technology. results：
the optimal preparation method was ethanol injection method； the optimal preparation technology were spc 4 mg in 1 ml lipid， the mass ratio of spc to ch 3 ∶ 1， the ratio of zto to lipid 1 ∶ 9 ， the ratio of tretinoin to lipid 1 ∶ 70， water bath temperature of 55 ℃. encapsulation efficiencies of zto and tretinoin were （64.63±1.
00）% and （90.33±0.72）% in 3 batches of ztoc-lps， respectively.
drug-loading amount of zto and tretinoin were （9.09±0.14）% and （1.
43±0.02）%， respectively. particle size was （257.
41±7.58） nm， zeta potential was （-38.77±0.
81） mv， pdi was 0.10±0.04； the results of centrifugal acceleration test showed that the liposomes had good physical stability.
no obvious change was found in each investigation index of ztoc-lps that stored at （4±2） ℃ for 1 month. conclusions： established preparation technology is ****** and feasible， the quality of the prepared ztoc-lps conforms to the requirements， and it can provide reference for the following research of ztoc-lps.